Type 2 Diabetes, Evidence-Based Medicine, and Real Human Welfare (Difficulty Level: Intermediate)
Warning: Persons with diabetes should not ever make ANY significant lifestyle changes without first reviewing such changes with their professional healthcare specialist. Coma and death are entirely possible via uncritical lifestyle change in diabetics. As always, the following is not to be interpreted as medical advice. Instead, it is merely an invitation regarding considerations which may prove useful for some individuals, some of the time.
Note: In the essay below, the term "diabetes" will refer to Type 2 Diabetes (unless otherwise specified).
The prevalence of Type 2 Diabetes has been growing exponentially for more than 80 years (1). It should be noted immediately that this sharp rise in prevalence debunks, at the outset, any and all theories on the etiology of diabetes which happen to place a heavy emphasis on "genetic" or other "un-modifiable" factors. Indeed, the only plausible explanations for sharp rises in the prevalence a human disease are those centered around modifiable factors - as they are the only things that can cause sharp rises.
That diabetes is indeed on the rise - and has been so for over 80 years - is evidenced by a recent article that reprints an historical quote (1) from its original source: a 1921 article in the Journal of the American Medical Association:
"There are entirely too many diabetic patients in the country. Statistics for the last thirty years show so great an increase in the number that, unless this were in part explained by a better recognition of the disease, the outlook for the future would be startling." -Elliot P. Joslin
The authors, who have quoted Joslin's words above for the 80-year perspective it provides, offer no comfort with their own synopsis of how this early concern has played out: " ... Joslin's vision of the future has become a reality." Instead, they offer such bleak snapshots and staggering conclusions as the following:
-more than 18 million Americans have diabetes
-the annual cost of the disease is estimated to be at least $132 Billion (more than 10% of US expenditures on health care services)
-in the next 50 years, the number of diagnosed diabetes cases is predicted to increase by 165% in the US
-for the cohort of Americans born in 2000, the estimated lifetime risk of diabetes is more than 1 in 3
Well, obviously, something is wrong with this picture - some error must be (and must always have been) in the making, for us to be so pitifully losing a health battle of this magnitude. An error which may - in the future - be recalled as the biggest blunder of modern medicine. But what is this fatal error of human thinking in the field of medicine? It is the lack of mental integration of available information (a "philosophical" error). Failing to properly integrate evidence leads to piecemeal analysis, and an unprincipled allocation of time and money aimed at poorly-defined (or elusive) targets for intervention. A failure of integration leads researchers down many blind-alleys as they only get a "snapshot" picture requiring much otherwise-preventable assumption (due to failed integration of previous facts) when viewing the evidence surrounding a given disease.
One strategy for integrating available evidence is to examine societies around the world to see if a problem - which is prevalent in one area of the world - is absent, or even much less prevalent, in another. If such a method is undertaken, then the next step (assuming you've found a stark contrast in the prevalence for a given disease) is to provide an explanation for the stark contrast found and, in doing so, to understand the mechanics behind the particular disease in question. Indeed, a few leads have already surfaced from this process - as applied to diabetes: relative muscularity, cell membrane composition (which is modifiable by diet) and dietary elements, like chromium and magnesium, have surfaced as biochemical explanations of the discovered differences in insulin-resistance and diabetes found round the world.
But, on a more somber note, this type of analysis is amazingly absent from the majority of professional articles on such an onerous disease as diabetes. To add insult to injury, the articles which do note geographical differences in diabetes prevalence, almost invariably make the mistaken assumption that genetics is the primary factor for the differences found. But, as I've proven in the first paragraph of this essay, sharp increases in prevalence disqualify "genetics" as a primary factor (additional weight to this line of argument - though not necessary for its finality - is added by the noted increased prevalance in those otherwise "genetically-protected" individuals after adopting the lifestyle of the "genetically-susceptible" individuals).
The grossest of errors lies not in failing to integrate evidence however, but in feigning to do so under the guise of a new paradigm: Evidence-Based Medicine (EBM). EBM is a new paradigm in medicine that supposedly enshrines evidential reasoning as the arbiter of truth and action in medicine. In other words, all medical decisions are to be weighed against all alternative decisions and the vast scientific literature is to be critically examined to place decisions in a hierarchy for proper medical practice.
I have to admit that I was, at first, taken in by the goals of EBM, which seemed to bring hope for a new level of objectivity in medicine. But this initial hope was clearly a premature evaluation and has been turned upside-down by the dominant professional application of EBM, which breaks down to merely finding the best evidence for things within a paradigm (see above) without questioning the paradigm itself. What EBM has done is to make decision-makers demand the most internally valid research (Randomized, Placebo-Controlled Trials) that has, by happenstance, been done.
What it HAS NOT DONE is to demand that research takes more valid directions, such as the integrative approach outlined above. So what we end up with is decision-making based on the "best-available evidence", but without any wisdom in research DIRECTION, we have substandard "evidence" to base decisions on. An analogy illustrating this inherent weakness of EBM is a dragster with 1000 horsepower, but no wheels to transfer the power into winning actual drag races (no amount of horsepower is useful unless the "rubber hits the road"). In short, if the only good evidence for an existing intervention happens to be a dangerous drug, then that drug will be used to the exclusion of alternatives which have "promise" but have not yet been through the rigorous type of investigation that the dangerous drug has gone through.
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Now that I have "trashed" EBM as the final solution to medical decision-making, I have to say that there is something to salvage in its aspirations. Recent attention was given to intervention alternatives for diabetes in an EBM review on the matter (2). This review reads like a literal "who's who" as far as promising, popular alternative interventions go (though little merit is awarded to these "alternatives" in this "evidence-based" review): "Attention is focused on dietary fiber, glycemic index, dietary protein, omega-3 fatty acids, chromium, magnesium, and vitamin E."
As stated above, this list of alternatives captures much of the promise available with complementary approaches to either 1) reverse diabetes, or 2) lessen its complications. The changes that I'd make to this list of alternatives (to make it more promisingly health-promoting) are:
1 - change "dietary fiber" to "soluble fiber" (insoluble fiber has relatively little effect on glycemic control)
2 - change "glycemic index" to "glycemic load" (higher glycemic index foods can often be used, if only judiciously, though the total load of such foods in a diet can "make or break" a lifestyle program aimed at glycemic control)
3 - change "dietary protein" to "% dietary protein" (to reveal the fact that low-protein diets - by increasing the total load of carbohydrates and fats to which we are exposed; 2 known triggers of diabetes in experiments - are inherently diabetogenic)
4 - change "omega-3 fatty acids" to "long-chain omega-3 fatty acids" (such as those found in fish)
5 - change "chromium" to "supplemental chromium" (to reflect the fact that the experimental doses of this nutrient that HAVE PROVEN USEFUL are in excess of that expected from even well-selected diets)
6 - change "vitamin E" to "supplemental vitamin E" for the same reason as above (in contrast, health-promoting doses of magnesium are easily attained with well-selected diets)
7 - add 150 minutes per week of moderate-to-high intensity exercise (to take advantage of this proven diabetes "intervention")
8 - include a restriction on alcohol consumption to 1-2 drinks per day
9 - include a special warning against most packaged foods (which often contain 2 of the most highly-suspected "diabetes-promoting" ingestibles available to humans: high-fructose corn syrup and trans fatty acids)
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Again, this essay is not meant as medical advice (or as any kind of substitute for medical advice). My only "advice" (if anything here is appealing to you) is to share these considerations with your professional healthcare specialist and discuss them rationally. Here is a utility-inspired outline of basic food choices for consideration:
Approximate Weekly Grocery List
A) Lean protein sources (per ounce: 7 grams protein; 0-3 grams fat)
2-3 pounds of boneless, skinless chicken or turkey breast
2-3 cans or foil-packs of tuna, salmon, or sardines (water packed)
2-3 dozen eggs (for veggie omelettes or hard-boiled eggs)
2-3 pounds of lean beef
B) Unrefined carbohydrate sources (cooked: 30-45 grams carbohydrate per cup)
1-2 boxes of brown rice
1-2 cans of Whole Oats
One 3-lb bag of sweet potatoes or yams
C) Fibrous, low-carb vegetable sources (5-15 grams carbohydrate per cup)
1-2 bags frozen mixed veggies (ones containing veggies of at least 3 different colors - green, red, yellow, orange, etc)
1-2 bags of fresh pre-mixed salad greens (ones containing veggies of at least 3 different colors - green, red, yellow, orange, etc)
*other prominent, single-veggie choices include: red & green pepper, onion, tomato, mushroom, asparagus, spinach, broccoli, romaine lettuce, red cabbage, parsley
D) Low glycemic-index Fruits (10-20 grams carbohydrate per cup)
melons
berries
citrus fruits
E) Miscellaneous:
1 container of saccharin, Sucralose, or Sunnette (sweeteners)
1 shaker of cinnamon
1 small bottle of extra-virgin olive oil
1 small bottle of balsamic vinegar
1 shaker of either Butter Buds or Molly McButter
1 aerosol can of Pam Butter spray
1 squeeze-bottle of lemon or lime juice (or 2 whole lemons or limes – to squeeze juice from)
1 bottle Mrs. Dash Salt-Free Seasoning (the "Table Blend" is suggested)
2-3 gallons of spring water (or distilled "drinking water" - with the added minerals)
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Very Rough Outline of Daily Meal Plan:
-more than 2 meals per day
-less than 500 total kcal per meal
-more than 25 grams of protein per meal (more than 100 kcal)
-less than 50 grams of carbohydrates per meal (less than 200 kcal)
-less than 20 grams of fat per meal (less than 180 kcal)
-green veggies with at least 2 of the daily meals
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Sample Day:
Meal #1:
4-egg (2 whole eggs + 2 egg whites) veggie omelette (w/green pepper, onion, tomato, mushroom) & 1/3 - 1/2 cup of oatmeal (w/cinnamon, sweetener, berries)
Meal #2:
"Colorful" Chef salad (w/chicken, beef, turkey, or tuna) & 1 medium sweet potato or 1/2 yam
Meal #3:
Meat/egg and broccoli stir-fry on 1/3 - 1/2 cup brown rice
Meal #4:
Steamed chicken breast AND steamed mixed veggies (seasoned to taste)
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References:
1. Williamson DF, et al. Primary prevention of type 2 diabetes by lifestyle intervention: implications for health policy. Ann Intern Med, 2004; 140(11):951-7
2. Neff LM. Evidence-based dietary recommendations for patients with type 2 diabetes mellitus. Nutr Clin Care, 2003; 6(2):51-61


